The Potency of Red Guava(Psidium Guajava L.)Extractas Antioxidant on

Cigarette Smoke Exposure in Mice lungs

Imam Thohari1, Rachmaniyah1, Umi Rahayu1
Page No. 11-15

Cigarette  smoke  can  cause  to  the  formation  of  an  oxidative  stress,  resulting    in    increase    in 
concentration    of    free    redicals  and  decrease  antioxidant. Psidium  guaya  Lextracthas  shown  to
possess powerful antioxidant properties. In the present study, we investigated the impact of Psidium
guaya Lextract in against Cigarette smoke -induced lung damage in mice. The 28 male mice were
divided into: negative control (mice were exposed with fresh air daily 1 h twice a day for 30 day) ;
positive  control  (Mice   were  exposed with  cigarette  smoke 1 h  twice a  day  for 30 days), and  the
treatment group (mice were given the Psidium Guajava Lextract 0.35 ppm, 0.70 ppm orally once in
a day for 34 days and on 4th day, were exposed with cigarette smoke 1 h twice a day for 30 days. On
day  34,the mice  were  sacrificed,  and  lung  tissues  were  collected  to  histological  evaluations.The
cigarette  smoke  significant  induced  necrosis  inlung  cell.  However,  treatment  with  the  Psidium
Guajava Lextract extract significantly  improvedlung cell damage.From  the results,  it  is concluded
that the Psidium Guajava Lextractare a potent antioxidantin against cigarette smoke-induced lung
damge in mice.
Keywords : Psidium Guajava L, Antioxidant, Lung, Cigarette smoke