Protective Effect of PsidiumGuajava L.)on SuperoxideDismutaseof Cigarette
Smoke Exposure in Mice

Rachmaniyah*, Rahayu U, Thohari I
Page No. 141-145

Background: Cigarette smoke that was accumulated on blood vessel membrane would constrict
smokers’ blood vessels. Free radicals which were from cigarette smoke would cause lipid
peroxidation of cell membranes, then, it would damage cell membrane organization. If free radicals
in the body increased continuously,it was needed enzymes in greater numbers to neutralize
superoxide dismutase (SOD). Antioxidants were substances that gave their electrons to free radical
molecules and could break the chain reaction of free radicals. Psidiumguaya L extract was a source
of anti-oxidants because they contained phenolic and ascorbic acid. Aim: To analyse the effect of
giving extracts of Psidiumguajava l as an antioxidant for the protection of cell membrane damage
due to cigarette smoke exposure. Method: This research was experimental laboratory by using
healthy male mice which aged 3-4 weeks, had weightin 25-40gr, were adapted for a week and then,
they were divided into 4 groups treated by cigarette smoke exposure and guava extract
(PsidiumGuajava L.). Afterwards, it was checked SOD activity levels of mice’ blood. Results: The
givingextract of Psidiumguajava L as an antioxidant was proven to give real effect to cell
membrane damage due to cigarette smoke exposure that was the increase of the content of
Superokside Dismustase (SOD)activity in mice. Conclusions: Psidiumguaya L extract possesses
antioxidative properties against cigarette smoke via augmentation of SOD activity
Keywords : Psidiumguajava l, Antioxidative, SOD,cigarette smoke.