Synthesis, characterization and biological evaluation of Sulfamethizole and
Maleic anhydride based transition metal complexes

Hitesh R Patel,a Asha D Patel*a
Page No. 1-7

In the present study a novel 4-{[4-(N-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl]amino}-4-
oxobut-2-enoic acid (MTSPAB) was prepared by reaction of maleic anhydride with Sulfamethizole.
The prepared ligand was characterized by elemental analysis and spectral studies. The transition
metal complexes viz. Cu2+,Ni2+ ,Co2+ ,Mn2+ and Zn2+ of MTSPAB were prepared and characterized
by metal-ligand (M:L)ratio,IR,reflectance spectroscopies and magnetic properties. All the prepared
metal complexes and ligand were studies as antimicrobial agent. Among all the metal complexes,
Zn2+ and Cu2+ metal complexes have shown significant activity.
Key Words: Maleic anhydride, Sulfamethizole, Magnetic moment, Spectroscopic study and
Antifungal properties.