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Effect of N-acetyl cysteine , Zinc oxide and high pH ascorbatenanocomposite against 7,12- dimethylbenz[a]anthracene-induced mammary gland carcinoma in female rats on caspase 3 & 9 genes and TNF-α level


Omayma A.R. AbouZaid1 ;Badawi A.F.2 and SamehA.Elsayes1
Page No.1-14


Abstract

7,12- dimethylbenz[a]anthracene ( DMBA) mediates carcinogenesis through formation of DNA
adducts, DNA damage, generating excess reactive oxygen species and by producing chronic
inflammation. N-acetyl cysteine , Zinc oxide and high pH ascorbate nanocomposite have been
shown to confer various biological effects, anticancer, enhance immune system and antioxidant
properties and induction of apoptosis. The present study was undertaken to evaluate the
chemopreventive effect of N-acetyl cysteine , Zinc oxide and high pH ascorbate nanocomposite
with dose 50mg/kg.b.w against 7,12- dimethylbenz[a]anthracene carcinogenesis with dose
100mg/kg.bw at the end of the second week (On day 16).Then, animals left until mammary gland
carcinoma formed. The results indicated that DMBA induced mammary gland carcinoma in rat
Also, significant increase in TNF-α and significant decrease incas3, cas9 activity. While, treating
with Nanocomposite decreasing in TNF-α and significant increase incas3, cas9 activity.
Keywords: Nanocomposite (N-acetyl cysteine, Zinc oxide and high pH ascorbate), TNF-α,
caspase3,caspase 9.


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