Brown tumors and hyperparathyroidism

Mouna Chafai1, Mariam Chettati1, Wafaa Fadili1, Inass Laouad1
Youness Ouadoudi2, Youssef Rochdi2, Hassan Nouri2, Lahcen Aderdour2, Abdelaziz Raji2

Page No. 8-22

Introduction:The brown tumor is a rare manifestation that represents a severe form of hyperparathyroidism. Materials and methods: This is a descriptive retrospective study over an 07-year period involving eight patients with hyperparathyroidism who presented with a brown tumor. Results:Fivepatients were followed for chronic end stage renal failure. Bone biopsies performed in three patients showed an appearance in favor of brown tumor. Cervical ultrasound revealed retro thyroid nodules in favor of bilateral parathyroid adenomas in five patients and parathyroid inferior adenoma in two cases. The biological assessment revealed a high value of parathyroid hormone with an average rate of 2031,5μg / ml. Secondary hyperparathyroidism was identified in five patients and primary in two patients. The surgical treatment consisted of a subtotal para thyroidectomy in five patients and excision of the parathyroid adenoma in two cases. Five patients developed postoperative hypocalcemia, one of which was severe, and benefited from medical management. Postoperative monitoring of parathyroid hormone showed a regression of serum values with an average value of 301 pg / ml at day 7. Conclusion: Brown tumors are rare in patients with hyperparathyroidism. Monitoring patients with chronic renal failure is essential to detect complications that may occur in these patients as is the case with brown tumors.
Keywords : brown tumor, hyperparathyroidism, chronic renal failure.