Adultceliac disease: correlation between Endoscopic, histological and
biological appearance

Raphaël SIDIBE (1), Imane. ELHIDAOUI (1),Fatim E. LAIRANI(1), Zouhour SAMLANI
(1), Khadija KRATI (1), Sofia OUBAHA (2)
Page No. 115-122

Introduction: The diagnosis of celiacdisease is based on the positivity of
Serological markers, histological criteria as well as the response to the gluten-free diet.
The aim of our work is to study the correlation between endoscopic, histological and serological
appearances. Patients and method: This is a retrospective descriptive studycarried out within 5-
year period from October 2010 to October 2016. The 25 patients in our Collected series in the
department of hepatogastroenterology of CHU Mohammed VI have benefited from an assessment
Serology, an endoscopy of the upper digestive track with biopsies and anatomopathological study of
the biopsies. Results: The meanage of our patients was 33 years [16-50],we noted a clear female
predominance. Chronicdiarrhea was the main indicator Foundin 70%. upper digestive
track endoscopy was normal in 40% of cases, showing duo denal fold serasedin 36% of cases, and
an aspect of duodenitisin 24% of cases. The anatomo-pathological study of the biopsies carried out
during the digestive endoscopy noted a total villous atrophyin 60% of cases, in 40% of cases it was
an atrophy. Subtotal of the villus. Serologically anti-transglutam in aseanti bodies were positive in
90% of cases, where as anti-endomysium antibodies were present in 65% of cases.The study of
correlation between the different erological, endoscopic and Histological aspect is not significant
in our series.Conclusion: In our series, thereis no significant correlation between the endoscopic
appearance, serological profile and degree of villousatrophy; This can be explained by the small
number of people for the study, hence the interest of other prospective studies with a large work
force.
Keywords : Caeliacdisease; Correlation; Endoscopy; Serology; histology.