Synthesis, Characterization And Anti Bacterial And Cytotoxic Studies Of Novel Chalcones From 2,4 Di Fluoro Acetophenone

CH.M.M.Prasada Rao*a,Rahaman S.Ab Rajendra Prasad Yejellac
Page No. 1-8

Chalcones were an important organic compounds for synthesis of different hetero cyclic
compounds contains five and six member nucleus. Most of these compounds are highly bioactive
and are widely used in pharmaceuticals. They belongs to an important class of flavonoids,
Chalcones are synthesized by Claisen–Schmidt condensation reaction , which involves cross aldol
condensation of appropriate aldehydes and ketones by base or acid catalysed reactions followed by
dehydration. 13 new Chalcones were synthesized. The structures of newly synthesized compounds
were confirmed by spectral evidence. Prepared compounds were tested for anti microbial activity
by using serial dilution method and cytotoxicity studies by MTT assay method.
Keywords: Chalcones, Antimicrobial Activity, antifungal activity and cytotoxicity.