Synthesis, characterization and antimicrobial studies of some Mannich bases derived from phenylethyl amine and their transition metal complexes

A. Abdul Jameel[1], M. Syed Ali Padusha[2] , K. Sulthan Syed Ibrahim[3*]
Page No. 5-11

In the present study, an attempt has been made to synthesize Mannich bases (L1 to L4) using 2-
phenylethylamine, benzaldehyde and amide moieties such as semicarbazide, thiosemicarbazide,
urea and thiourea are employed as compound containing active hydrogen atom. Mannich bases
thus formed were characterized by physical methods such as TLC, elemental analysis and melting
point. Metal complexes of [MCl2(L1)2], [M(L1)2(H2O)2]Cl2 [M=Co(II), Ni(II), Cu(II) and Zn(II)] of
ligand (L1) were also prepared. The structures of newly synthesized compounds, complexes, mode
of binding and overall geometry were characterized through electronic, IR, 1H NMR, 13C NMR and
Mass spectral studies. Elemental analysis, conductance measurements, TGA and DTA studies have
been characterized to establish the structure of complexes. In vitro antimicrobial studies of L1
ligand and its transition metal complexes and all other Mannich bases L2 to L4 were recorded
against certain pathogenic Gram positive bacteria such as S. aureus, S. faecalis and certain
pathogenic Gram negative bacteria such as E. Coli, P. aeruginosa, along with antifungal activity
against C. albicans.
Keywords: Metal complexes of Mannich base, Multicomponent reaction, NO donors 2-
phenylethylamine, Antimicrobial activities