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β-Cyclodextrin catalyzed synthesis of 2-oxoindolin-3-ylidene malononitrile derivatives in water


Mehdi Abaszadeh[1], Mohammad Seifi[2]
Page No. 128-131


Abstract

Knoevenagel condensation of isatins with malononitrile has been carried using biomimetic catalyst,
β-cyclodextrin in water at 60 °C and obtained 2‐oxoindolin‐3‐ylidene malononitrile derivatives with
excellent yields and shorter reaction times. The β-cyclodextrin can be recovered and reused a
number of times without any loss of activity.
Keywords : β-Cyclodextrin, Knoevenagel condensation, 2‐oxoindolin‐3‐ylidene malononitrile
derivatives.


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